tp53 R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome Phenotypes
Kim Kobar, Lissandra Tuzi, Jennifer A. Fiene, Erin Burnley, Kristianne J. C. Galpin, Craig Midgen, Brianne Laverty, Vallijah Subasri, Timmy T. Wen, Martin Hirst, Michelle Moksa, Annaïck Carles, Qi Cao, Adam Shlien, David M. Malkin, , Jason N. Berman
This study characterizes zebrafish models of Li-Fraumeni syndrome with TP53 mutations, showing dysfunctional p53 pathways, tumor development, and mutation-specific phenotypes.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · Dec 4, 2024Peer-reviewedCancer Biology