Kim Kobar

The paper demonstrates that sulanemadlin, a stapled peptide inhibitor of MDM2, specifically activates p53 in zebrafish without inducing apoptosis, enabling direct in vivo studies of p53 regulation.

This study characterizes zebrafish models of Li-Fraumeni syndrome with TP53 mutations, showing dysfunctional p53 pathways, tumor development, and mutation-specific phenotypes.