Jason N. Berman

A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafish

The paper demonstrates that sulanemadlin, a stapled peptide inhibitor of MDM2, specifically activates p53 in zebrafish without inducing apoptosis, enabling direct in vivo studies of p53 regulation.

tp53 R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome Phenotypes

This study characterizes zebrafish models of Li-Fraumeni syndrome with TP53 mutations, showing dysfunctional p53 pathways, tumor development, and mutation-specific phenotypes.

CRISPR Knock-in Designer: automatic oligonucleotide design software to introduce point mutations using CRISPR/Cas9

CRISPR Knock-in Designer automatically designs DNA oligonucleotides for precise point mutations using CRISPR/Cas9, supporting various experimental strategies and genomic contexts.

Successful optimization of CRISPR/Cas9-mediated defined point mutation knock-in using allele-specific PCR assays in zebrafish

The paper optimizes CRISPR/Cas9-mediated point mutation knock-in in zebrafish using allele-specific PCR assays and identifies key factors improving knock-in efficiency and reducing false positives.