Next-generation genetically encoded biosensors for spatiotemporal intracellular pH monitoring, mapping, and profiling
Sam Taylor, Bruno Colon, Kyutae D Lee, Jennifer Arcuri, Shraddha ChandThakuri, Daniel G. Isom
This paper develops ORION, a genetically encoded BRET pH sensor with improved performance and broader pH range, and demonstrates its use in identifying acid imprinting states in cancer cells.
bioRxiv · May 22, 2026 · PreprintBiochemistry