Cryo-EM Structures of Amyloid-β 42 Filaments from Human Brain
Yang Yang, Diana Arseni, Wenjuan Zhang, Melissa Huang, Sofia Lövestam, Manuel Schweighauser, Abhay Kotecha, Alexey G. Murzin, Sew Y. Peak-Chew, Jennifer Macdonald, Isabelle Lavenir, Holly J. Garringer, Ellen Gelpí, Kathy L. Newell, Gabor G. Kovacs, , Michel Goedert
Cryo-EM shows brain-derived Aβ42 filaments adopt two related S-shaped protofilament folds: Type I dominates sporadic Alzheimer's, Type II familial Alzheimer's, other disorders and App^NL-F knock-in mice.
Science · Jan 14, 2022Peer-reviewedNeuroscience✦ In-depth digest