Single dose alum adjuvanted RBD protein vaccine provides protection against homologous challenge with SARS-CoV-2 Washington strain and heterologous rechallenge with Delta and Omicron BA.5 variants in K18 hACE2 mouse model
Rajesh Thippeshappa, Viraj Kulkarni, Varun Dwivedi, Jennifer McMillian, Marco Argonza, Joshua Castro, Oscar L. Rodriguez, Billie Maingot, Michal Gaži, Reagan J. Meredith, Deepak Kaushal, Ricardo Carrion
A single dose of alum-adjuvanted RBD protein vaccine from the Wuhan strain protects against homologous SARS-CoV-2 WA strain challenge but not heterologous Delta and Omicron BA.5 rechallenge, unless mice survive the initial WA challenge.
bioRxiv · Sep 18, 2025 · PreprintMicrobiology