Deepak Kaushal

This study shows that D-1MT treatment enhances CD8+ T cell infiltration and interactions with macrophages in TB granulomas, improving immune control of Mtb.

This study shows that an attenuated Mycobacterium tuberculosis vaccine induces bronchus-associated lymphoid tissue (iBALT) and protects against heterologous TB challenge in macaques.

This study shows mast cells drive tuberculosis pathology by promoting inflammation and Mtb dissemination, with distinct transcriptional programs in active versus latent infection.

The paper introduces a method using Imaris to track PET-defined lung inflammation sites in Mtb-exposed NHPs, showing correlation with traditional methods and providing additional lesion features.

A single dose of alum-adjuvanted RBD protein vaccine from the Wuhan strain protects against homologous SARS-CoV-2 WA strain challenge but not heterologous Delta and Omicron BA.5 rechallenge, unless mice survive the initial WA challenge.

This study identifies PU.1 as a key transcription factor regulating epigenetic responses to Mtb, showing its role in supporting infection and potential as a therapeutic target.

The paper shows that targeted breeding strategies in rhesus macaques reduced SIV-refractory MHC haplotypes without decreasing genetic diversity.