Author

Joshua Castro

Texas Biomedical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:chicken / avian· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Adolfo García‐SastreiD· 2 shared Aitor NogalesiD· 2 shared Chengjin YeiD· 2 shared Luis Martínez‐SobridoiD· 2 shared Michal Gaži· 2 shared Ramya S. BarreiD· 2 shared Ricardo CarrioniD· 2 shared Roy N. PlattiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Adolfo García‐SastreORCID

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3 papers

Recent·Most cited

Enhanced Pathogenicity and Contact Transmissibility of Human-origin Avian Influenza H5N1 Clade 2.3.4.4b Genotype B3.13 Compared to D1.1 in Ferrets

Elsayed M. Abdelwhab, Ramya S. Barre, Mahmoud M. Bayoumi, Alvaro Padrón, Hossein Batebi, Vinay Shivanna, Roy N. Platt, Fiona Burmeister, Joshua Castro, Arash Rahmani, Chengjin Ye, Timothy J. C. Anderson, Roland R. Netz, Aitor Nogales, Robert P. de Vries, , Luis Martínez‐Sobrido

This study compares the pathogenicity and transmissibility of two H5N1 genotypes in ferrets, finding B3.13 is more pathogenic and transmissible than D1.1, while D1.1 acquires adaptive mutations rapidly.

bioRxiv · Aug 19, 2026 · PreprintMicrobiology

Single dose alum adjuvanted RBD protein vaccine provides protection against homologous challenge with SARS-CoV-2 Washington strain and heterologous rechallenge with Delta and Omicron BA.5 variants in K18 hACE2 mouse model

Rajesh Thippeshappa, Viraj Kulkarni, Varun Dwivedi, Jennifer McMillian, Marco Argonza, Joshua Castro, Oscar L. Rodriguez, Billie Maingot, Michal Gaži, Reagan J. Meredith, Deepak Kaushal, Ricardo Carrion

A single dose of alum-adjuvanted RBD protein vaccine from the Wuhan strain protects against homologous SARS-CoV-2 WA strain challenge but not heterologous Delta and Omicron BA.5 rechallenge, unless mice survive the initial WA challenge.

bioRxiv · Sep 18, 2025 · PreprintMicrobiology

A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions

Ramya S. Barre, Ruby A. Escobedo, Esteban M. Castro, Michal Gaži, Joshua Castro, Anastasija Čupić, Mahmoud Bayoumi, Nathaniel D. Jackson, Chengjin Ye, Aitor Nogales, Roy N. Platt, Ricardo Carrion, Timothy J. C. Anderson, Adolfo García‐Sastre, Ahmed Mostafa, Luis Martínez‐Sobrido

This paper develops a bioluminescent H5N1 influenza virus to track infection and test antiviral drugs in vitro and in vivo.

iScience · Aug 21, 2025Peer-reviewedMicrobiology