Valerie Marie Weaver

This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.

The paper shows that tissue tension enables Src-mediated β-catenin phosphorylation, which is critical for mesoderm specification in human embryonic stem cells.

This study identifies NCOR2 as an epigenetic repressor of MHC class I expression in breast cancer, promoting metastasis by inhibiting immune surveillance.

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

This study shows that YAP activation in monolayer cultures causes resistance to EGFR/KRAS/BRAF pathway inhibitors, while spheroids are more sensitive, highlighting differences in culture systems for modeling cancer progression.

This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

The paper uses single-cell RNA sequencing to analyze murine pancreatic duct cells, identifying heterogeneity and functional roles in disease progression.

The paper shows engineered substrates promoting cell-cell adhesion drive gastrulation-like self-organization in hESCs by enhancing cell tension and Wnt signaling to specify mesoderm.