Author

Jenny Shi

MRC Laboratory of Molecular BiologyPrimary ORCID profile (0000-0003-1643-4789 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jenny ShiiD2 papers · Stanford Medicine

Biology Disciplines

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Biophysics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1

Frequent Co-Authors

Sjors H. W. ScheresiD· 3 shared Sofia LövestamiD· 3 shared Michel GoedertiD· 2 shared Alexey G. Murzin· 1 shared Chao QiiD· 1 shared David Li· 1 shared Harro SeelaariD· 1 shared Jane L. Wagstaff· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

Sjors H. W. ScheresORCID

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3 papers

Recent·Most cited

The Pick fold in tau filaments from human MAPT mutants

Chao Qi, Sofia Lövestam, Jenny Shi, Alexey G. Murzin, Sew‐Yeu Peak‐Chew, Thomas T. Warner, Harro Seelaar, Patrick W. Cullinane, Zane Jaunmuktane, John Cornelis Van Swieten, Sjors H. W. Scheres, Michel Goedert

This study reports cryo-EM structures of tau filaments from MAPT mutants, showing how specific mutations alter the Pick fold structure and enable reconstitution of variants.

Acta Neuropathologica · Jul 8, 2026Peer-reviewedBiophysics

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

Sofia Lövestam, Jane L. Wagstaff, Taxiarchis Katsinelos, Jenny Shi, Stefan M.V. Freund, Michel Goedert, Sjors H. W. Scheres

This study identifies twelve phosphomimetic mutations in tau that induce the formation of paired helical filaments in vitro, mimicking Alzheimer's disease structures.

eLife · May 20, 2026Peer-reviewedNeuroscience

Cryo-EM image processing of amyloid filaments in RELION-5.1

Sofia Lövestam, Jenny Shi, David Li, Kiarash Jamali, Sjors H. W. Scheres

The paper introduces new tools in RELION-5.1 for automated processing and analysis of cryo-EM images of amyloid filaments, demonstrating their application on experimental datasets.

bioRxiv · Mar 17, 2026 · PreprintBiophysics