Author

Jane L. Wagstaff

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Stefan M.V. FreundiD· 3 shared Sjors H. W. ScheresiD· 2 shared Alexander F. SchubertiD· 1 shared Anna AlbeckaiD· 1 shared Anna Victoria ProtasioiD· 1 shared Christina GladkovaiD· 1 shared Christopher G. TateiD· 1 shared Christopher H. DouseiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMolecular Biology

Stefan M.V. FreundORCID

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Author profile →

4 papers

Recent·Most cited

De novo design of flexible protein interactions with GuideFlip

Kai Yi, Qingchao Chen, Dongqi Zhang, Pengfei Tian, Jane L. Wagstaff, Stephen H. McLaughlin, Christopher G. Tate, Kiarash Jamali, Sjors H. W. Scheres

GuideFlip co-designs protein structure and sequence for flexible targets, improving in silico success rates and experimentally validating binders to disordered proteins.

bioRxiv · Sep 30, 2026 · PreprintBiophysics

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

Sofia Lövestam, Jane L. Wagstaff, Taxiarchis Katsinelos, Jenny Shi, Stefan M.V. Freund, Michel Goedert, Sjors H. W. Scheres

This study identifies twelve phosphomimetic mutations in tau that induce the formation of paired helical filaments in vitro, mimicking Alzheimer's disease structures.

eLife · May 20, 2026Peer-reviewedNeuroscience

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna Victoria Protasio, Marta Seczyńska, Daniil M. Prigozhin, Anna Albecka, Jane L. Wagstaff, James C. Williamson, Stefan M.V. Freund, Paul J. Lehner, Yorgo Modis

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

Nature Communications · Oct 2, 2020Peer-reviewedMolecular Biology

An "invisible" ubiquitin conformation is required for efficient phosphorylation by PINK1

Christina Gladkova, Alexander F. Schubert, Jane L. Wagstaff, Jonathan N. Pruneda, Stefan M.V. Freund, David Komander

The paper shows that an 'invisible' conformation of ubiquitin enhances its phosphorylation by PINK1 through a dynamic equilibrium involving the Ser65 loop.

The EMBO Journal · Nov 13, 2017Peer-reviewedMolecular Biology