Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
Qian Wang, Yicheng Guo, Ryan G. Casner, Jian Yu, Manoj S. Nair, Jerren Ho, Eswar R. Reddem, Ian A. Mellis, Madeline Wu, Chih-Chen Tzang, Hsiang Hong, Yaoxing Huang, Lawrence S. Shapiro, Lihong Liu, David D. Ho
This study optimizes a human monoclonal antibody to enhance its neutralization of SARS-CoV-2 variants, including subvariants XEC and LP.8.1, through structural analysis and engineering.
Nature Communications · Jul 4, 2025Peer-reviewedMicrobiology