Lawrence S. Shapiro

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

This paper uses free energy perturbation (FEP) calculations to predict and improve the accuracy of Fc-FcRn binding energy changes due to mutations, incorporating conformational changes and coupling effects.

This study generates 19 human monoclonal antibodies to track antigenic evolution of H5N1 clade 2.3.4.4b, identifying epitope-specific neutralization patterns and antigenic differences between viral genotypes.

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

The paper shows Dpr4/DIP-{Theta} transneuronal interactions control branch-specific axon pruning in Drosophila mushroom body neurons, with N-Cadherin mediating this process.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

FETCH enables precise fluorescent labeling of membrane proteins in Drosophila with spatiotemporal control through covalent bond formation.

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

This study optimizes a human monoclonal antibody to enhance its neutralization of SARS-CoV-2 variants, including subvariants XEC and LP.8.1, through structural analysis and engineering.

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

The paper shows that DIPs and Dprs interact in cis within the same cells, regulating trans interactions and influencing neural development in Drosophila.

The paper reports the cryo-EM structure of H5N1 hemagglutinin showing an auto-glycan from N169 binds the receptor-binding site, highlighting auto-glycan recognition in zoonotic transmission.

This study examines how recurrent spike mutations in SARS-CoV-2 JN.1 sublineages affect immune evasion, ACE2 affinity, and infectivity, identifying growth advantages in specific sublineages.

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

The paper investigates how varying affinities of CAM interactions affect synaptic targeting and neuronal survival in Drosophila, finding different affinity requirements for these processes.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

cAb-Rep is a curated database of human B cell immunoglobulin sequence repertoires, providing annotated datasets for studying antibody diversity and prevalence.

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.