The paper examines how immune reconstitution and antigenic exposure history influence virus-specific humoral immunity in HIV-treated individuals, finding varied relationships across different viruses.

bioRxiv · Sep 30, 2026 · PreprintImmunology

Antibody Responses Against Coronaviruses in the Wuhan Population

Shixiong Zhou, Cong Liu, Weiyong Liu, Kun Cai, Ke Lan, Chengliang Zhu, Qian Wang, Lihong Liu

The paper assesses neutralizing antibody responses to multiple coronaviruses in Wuhan population samples before and after the pandemic, finding enhanced cross-neutralizing activity against sarbecoviruses.

bioRxiv · Feb 17, 2026 · PreprintMicrobiology

Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2

Qian Wang, Yicheng Guo, Ryan G. Casner, Jian Yu, Manoj S. Nair, Jerren Ho, Eswar R. Reddem, Ian A. Mellis, Madeline Wu, Chih-Chen Tzang, Hsiang Hong, Yaoxing Huang, Lawrence S. Shapiro, Lihong Liu, David D. Ho

This study optimizes a human monoclonal antibody to enhance its neutralization of SARS-CoV-2 variants, including subvariants XEC and LP.8.1, through structural analysis and engineering.

Nature Communications · Jul 4, 2025Peer-reviewedMicrobiology

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana C. Chang, Ahmed Mostafa, Madhubanti Basu, Sanghita Sarkar, Simran Panjwani, Yaelyn H. Ha, Yao Ma, Chengjin Ye, Qian Wang, Todd Jason Green, James L. Kizziah, Nathaniel B. Erdmann, P. A. Goepfert, , James J. Kobie

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

npj Viruses · Nov 14, 2024Peer-reviewedImmunology

Robust SARS-CoV-2 Neutralizing Antibodies Sustained through Three Months Post XBB.1.5 mRNA Vaccine Booster

Qian Wang, Ian A. Mellis, Yicheng Guo, Carmen Gherasim, Riccardo Valdez, Aubree Gordon, David D. Ho, Lihong Liu

This study shows that neutralizing antibodies against SARS-CoV-2 variants remain stable for three months after an XBB.1.5 mRNA vaccine booster.

Cell Reports Medicine · Aug 28, 2024Peer-reviewedImmunology