Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion
Xavier Robin, Franziska Völlmy, Jesper Ferkinghoff‐Borg, Conor J Howard, Tom Altenburg, Mathias Engel, Craig D. Simpson, Gaye Saginc, Simon Koplev, Edda Klipp, James Longden, Rune Linding
The paper introduces a Bayesian method to estimate protein concentrations and phosphorylation site occupancy ratios from mass spectrometry data, applied to study PRKAR1A-RET gene fusion effects.
bioRxiv · Apr 29, 2019 · PreprintSystems Biology