Author

Jesse Luke

Roswell Park Comprehensive Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alfiya F. SafinaiD· 1 shared Ayah Anwar Mohammad Dar Salameh· 1 shared Brian Buckley· 1 shared Costakis G. FrangouiD· 1 shared Daniel Diaz· 1 shared Jianmin WangiD· 1 shared Katerina I. LeonovaiD· 1 shared Katerina V. GurovaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alfiya F. SafinaORCID

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1 paper

Recent·Most cited

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers.

Costakis G. Frangou, Alfiya F. Safina, Mairead Commane, Vidula Jadhav, Ayah Anwar Mohammad Dar Salameh, Brian Buckley, Prashant Singh, Jesse Luke, Daniel Diaz, Katerina I. Leonova, Jianmin Wang, Katerina V. Gurova

This paper investigates why oncogenic mutations often fail to induce cancer by showing that normal cells undergo a transient, plastic state but are constrained by lineage-specific barriers preventing stable transformation.

bioRxiv · Aug 6, 2026 · PreprintCancer Biology