Vidula Jadhav

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers.

This paper investigates why oncogenic mutations often fail to induce cancer by showing that normal cells undergo a transient, plastic state but are constrained by lineage-specific barriers preventing stable transformation.

Image-Based Quantitative Single-Cell Method Suggests Increase of Global Chromatin Accessibility in Tumor Compared to Normal Cells lines

The paper introduces an image-based method to measure chromatin accessibility using DNA-binding fluorescent molecules and finds higher accessibility in tumor compared to normal cells.