Prashant Singh

This paper investigates why oncogenic mutations often fail to induce cancer by showing that normal cells undergo a transient, plastic state but are constrained by lineage-specific barriers preventing stable transformation.

This study shows RB1 loss in EGFR mutant lung cancer leads to reversible lineage plasticity, accelerating resistance to EGFR TKI therapy through non-genetic mechanisms.

The paper introduces two ultrasmall chemogenetic tags, mgTag and cTag, which enable group-transfer reactions to append moieties to proteins, demonstrating their utility in cell signaling and proximity induction.