Author

Costakis G. Frangou

Roswell Park Comprehensive Cancer CenterORCID 0009-0006-5128-3161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Alfiya F. SafinaiD· 2 shared Jianmin WangiD· 2 shared Katerina I. LeonovaiD· 2 shared Katerina V. GurovaiD· 2 shared Andrei V. GudkoviD· 1 shared Ayah Anwar Mohammad Dar Salameh· 1 shared Brian Buckley· 1 shared Britney Lipchick· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Alfiya F. SafinaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 6, 2026

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers.

Costakis G. Frangou, Alfiya F. Safina, Mairead Commane…·Katerina V. Gurova

This paper investigates why oncogenic mutations often fail to induce cancer by showing that normal cells undergo a transient, plastic state but are constrained by lineage-specific barriers preventing stable transformation.

DOI 10.64898/2026.08.05.743116

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJun 28, 2017

Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule

Katerina I. Leonova, Alfiya F. Safina, Elimelech Nesher…·Katerina V. Gurova

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.

DOI 10.1101/142471

experimental assay

𝕏 PostBluesky