Nucleolar accumulation of APE1 through condensates is mediated by rRNA forming G-quadruplex structures
Giuseppe Dall’Agnese, Nancy M. Hannett, Kalon J. Overholt, Jesse M. Platt, Jonathan E. Henninger, Asier Marcos-Vidal, Giulia Antoniali, Gianluca Tell
This study creates an endogenous fluorescent APE1 cell line to show that APE1 accumulates in nucleoli via RNA G-quadruplex structures and lysine residues, linking phase separation to its functional switch between rRNA processing and DNA repair.
bioRxiv · Mar 4, 2024 · PreprintMolecular Biology