Gianluca Tell

This study investigates APE1's role in repairing damaged telomeric i-motif structures and its interaction with PCBP1 in maintaining telomere integrity.

This study identifies small molecule inhibitors of hnRNPA2B1-RNA interactions and shows they alter EV-RNA composition and paracrine signaling.

The paper identifies APE1-dependent miRNAs secreted via exosomes, showing their prognostic significance in cancer and their regulation by APE1 and hnRNPA2B1.

This study creates an endogenous fluorescent APE1 cell line to show that APE1 accumulates in nucleoli via RNA G-quadruplex structures and lysine residues, linking phase separation to its functional switch between rRNA processing and DNA repair.

This study identifies APE1 as an RNA G-quadruplex binding protein that regulates miR-92b expression by modulating rG4 structure folding and miRNA maturation in cancer cells.

The paper investigates the role of phase partitioning in DNA damage response by analyzing APE1's interactome for signs of liquid-liquid phase separation.