Jonathan E. Henninger

RNA-binding proteins activate transcription through defined molecular grammars

The paper identifies RNA-binding proteins (RBPs) that activate transcription through molecular grammars similar to transcription factors, revealing their role in transcriptional regulation and RNA processing.

Active RNA synthesis patterns nuclear condensates

The paper investigates how active RNA synthesis influences nuclear condensate patterning by studying nucleolar fibrillar centers and shows that RNA synthesis affects their size, number, and spacing.

Nucleolar accumulation of APE1 through condensates is mediated by rRNA forming G-quadruplex structures

This study creates an endogenous fluorescent APE1 cell line to show that APE1 accumulates in nucleoli via RNA G-quadruplex structures and lysine residues, linking phase separation to its functional switch between rRNA processing and DNA repair.

Transcription factors interact with RNA to regulate genes

The paper identifies RNA-binding as a common feature of transcription factors, showing it contributes to gene regulation and is conserved in vertebrates.

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

Generation of Mouse-Zebrafish Hematopoietic Tissue Chimeric Embryos for Hematopoiesis and Host-Pathogen Interaction Studies

This study xenografts murine bone marrow cells into zebrafish embryos to study hematopoiesis and host-pathogen interactions, showing successful integration and immune response.