Disrupting USP39 deubiquitinase Function Impairs the Survival and Migration of Multiple Myeloma Cells through ZEB1 Degradation
Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Coline Savy, Victoria J. Nicolini, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickaël Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pagès, Frédéric Luciano
This study identifies USP39 as a critical survival and migration factor in multiple myeloma cells, showing that its disruption leads to ZEB1 degradation and reduced tumor growth.
Journal of Experimental & Clinical Cancer Research · Dec 30, 2024Peer-reviewedCancer Biology