Marcel Deckert

The paper develops CytoFRET2 to monitor cytoskeletal dynamics and identifies KAT inhibitors as modulators of vimentin assembly.

This study shows that ECM stiffness influences dedifferentiated melanoma cells via DDR1/2 and YAP, affecting their behavior and drug resistance.

This study identifies PSMD14 as a key driver of melanoma survival and resistance to MAPK inhibitors by deubiquitinating histone H2A, altering chromatin state and gene expression.

This study identifies USP9X as a mechanosensitive deubiquitinase that stabilizes YAP to enhance tumor cell invasiveness and drug resistance.

This study identifies USP39 as a critical survival and migration factor in multiple myeloma cells, showing that its disruption leads to ZEB1 degradation and reduced tumor growth.