Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations
Tong Xu, Vera Janssen, Nathalie R. Reinhard, Paula Sobrevals Alcaraz, Robert M. van Es, Annett de Haan, JF Swart, Martijn Wehrens, Albert Wolkerstorfer, Chantal M.A.M. van der Horst, Harmjan R. Vos, Stephan Huveneers
This study identifies a calcineurin-NFAT-DSCR1.4 signaling axis driven by Gq-R183Q mutation in endothelial cells, showing its role in capillary malformations and potential as a therapeutic target.
bioRxiv · Jun 7, 2025 · PreprintCell Biology