Paula Sobrevals Alcaraz

The paper uses single-cell proteomics to show that GFAP mutations in Alexander disease lead to ETC dysfunction and metabolic adaptation via the G3P shuttle.

SCISSOR infers global translation activity in single cells using ribosomal RNA protection signatures, revealing cell cycle and differentiation-related translation variations in human and murine cells.

This study shows that localized hydrogen peroxide production induces p53-dependent resistance to DNA damage, with implications for chemotherapy protection.

This paper bioengineers matrix vesicles from hypertrophic cartilage microtissues to enhance bone regeneration by improving their yield and therapeutic potential through BMP2 and hypertrophic conditioning.

The paper identifies phosphorylation of membrane trafficking regulators, particularly SEC16A, as key to FER-mediated invasion in TNBC organoids.

This study identifies 16 kinetochore proteins in Tetrahymena thermophila, revealing both conventional and unconventional components that contribute to its unique kinetochore structure.

This study identifies a calcineurin-NFAT-DSCR1.4 signaling axis driven by Gq-R183Q mutation in endothelial cells, showing its role in capillary malformations and potential as a therapeutic target.