Harmjan R. Vos

Single Cell Proteomics reveals partial uncoupling of the Glycerol-3-Phosphate shuttle to compensate for Electron Transport Chain dysfunction in Alexander Disease GFAP mutations

The paper uses single-cell proteomics to show that GFAP mutations in Alexander disease lead to ETC dysfunction and metabolic adaptation via the G3P shuttle.

Single-Cell Inference of Structural States Of Ribosomes

SCISSOR infers global translation activity in single cells using ribosomal RNA protection signatures, revealing cell cycle and differentiation-related translation variations in human and murine cells.

Degenerated intervertebral disc environment impairs notochordal cell-derived extracellular vesicles release and their matrix anabolic effect

This study shows that degenerative disc conditions reduce notochordal cell-derived extracellular vesicles release and their ability to promote matrix production in nucleus pulposus cells.

Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent manner.

This study shows that localized hydrogen peroxide production induces p53-dependent resistance to DNA damage, with implications for chemotherapy protection.

Bioengineering Developmentally Inspired Matrix Vesicles as Designer Nanotherapeutics for Bone Regeneration

This paper bioengineers matrix vesicles from hypertrophic cartilage microtissues to enhance bone regeneration by improving their yield and therapeutic potential through BMP2 and hypertrophic conditioning.

Multi-omics analysis of TNBC organoids identifies phosphorylation of the membrane trafficking machinery as a key event associated with FER-mediated invasion

The paper identifies phosphorylation of membrane trafficking regulators, particularly SEC16A, as key to FER-mediated invasion in TNBC organoids.

Unconventional components complement the cryptic kinetochore of the ciliate Tetrahymena thermophila

This study identifies 16 kinetochore proteins in Tetrahymena thermophila, revealing both conventional and unconventional components that contribute to its unique kinetochore structure.

Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations

This study identifies a calcineurin-NFAT-DSCR1.4 signaling axis driven by Gq-R183Q mutation in endothelial cells, showing its role in capillary malformations and potential as a therapeutic target.

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.