Stephan Huveneers

Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations

This study identifies a calcineurin-NFAT-DSCR1.4 signaling axis driven by Gq-R183Q mutation in endothelial cells, showing its role in capillary malformations and potential as a therapeutic target.

VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and leukocyte extravasation

This study shows that VE-cadherin RGD motifs are not essential for endothelial cell-cell junctions, barrier function, or leukocyte extravasation.

Ultrasound-activated microbubbles mediate F-actin disruptions and endothelial gap formation during sonoporation

This study shows ultrasound-activated microbubbles disrupt F-actin and create endothelial gaps, facilitating drug delivery through sonoporation.

Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

Hematopoietic Stem And Progenitor Cells Use Podosomes To Transcellularly Home To The Bone Marrow.

This study shows that VE-cadherin regulates bone marrow vascular permeability and hematopoietic stem and progenitor cell (HSPC) homing, with HSPCs using podosomes to transcellularly enter the bone marrow.