TrAEL-seq captures DNA replication dynamics in mammalian cells
Neesha Kara, Laura Biggins, Vera V. Grinkevich, Alex J. Whale, Paola Garran-Garcia, Jhanavi Srinivasan, Peter J. Rugg‐Gunn, Simon Andrews, Aled Parry, Helen M.R. Robinson, Jonathan M. Houseley
TrAEL-seq is a method for profiling DNA replication dynamics in mammalian cells without requiring synchronization or drugs, showing replication fork speed and initiation zone effects.
bioRxiv · Jun 9, 2025 · PreprintMolecular Biology