Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapy
Joseph Clarke, Haoqi Chen, Cristina Tormo Garcia, Ewa Basiarz, Mateusz Kotowski, Ana Mafalda Santos, Mai T Voung, Paige A Sherman, Jia Xin Li, Christopher J. Tape, Simon J. Davis, Evangelia Petsalaki, Sumana Sharma
This study maps the NFκB pathway in T-cells using CRISPR screens and identifies novel regulators that enhance cytotoxicity and cytokine production.
bioRxiv · Feb 23, 2026 · PreprintImmunology