Haoqi Chen

This study maps the NFκB pathway in T-cells using CRISPR screens and identifies novel regulators that enhance cytotoxicity and cytokine production.

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

phuEGO reconstructs active signalling pathways from phosphoproteomics data by combining network propagation and decomposition to improve functional interpretation.

This paper develops a photo-switchable isocitrate dehydrogenase in yeast to dynamically control citric acid cycle flux using optogenetics.