Ana Mafalda Santos

Spatially patterned, spectral single-molecule microscopy

This paper introduces a new spectral single-molecule microscopy technique using spatially patterned detectors, achieving spectral and positional resolution without complex optical components.

Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapy

This study maps the NFκB pathway in T-cells using CRISPR screens and identifies novel regulators that enhance cytotoxicity and cytokine production.

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma

This study reveals how ARID1A-mediated transcriptional rewiring drives resistance to MAPK inhibitors in melanoma by altering signalling pathways, immune interactions, and receptor dynamics, highlighting potential targets for combinatorial therapies.

Cell state and transcription factor modulation during extended ex vivo CD8+ T-cell expansion.

The paper uses bulk RNA-seq and single-cell RNA-seq data to study T-cell expansion and identifies FOSL1 as a transcription factor that promotes an effector phenotype, enhancing cancer-cell killing.