The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2.
Jialin Feng, Mara Carreño, Hannah Jung, Sharadha Dayalan Naidu, Nicole M. Arroyo-Díaz, Abel Damien Ang, Bhargavi Kulkarni, Dorothy Kisielewski, Takafumi Suzuki, Masayuki P. Yamamoto, John D. Hayes, Tadashi Honda, Landon Shay Wilson, Beatriz León, Aimee L. Eggler, , Albena T. Dinkova‐Kostova
This study shows that kynurenine-CKA targets C151 in Keap1 to increase Nrf2 activity and anti-inflammatory effects in macrophages.
Redox Biology · Jan 6, 2026Peer-reviewedBiochemistry