Author

Sharadha Dayalan Naidu

University of DundeeORCID 0000-0002-7692-5611Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Albena T. Dinkova‐KostovaiD· 2 shared Abel Damien AngiD· 1 shared Aimee L. EggleriD· 1 shared Ana Rita CarlosiD· 1 shared Beatriz LeóniD· 1 shared Bérénice Saget· 1 shared Bhargavi Kulkarni· 1 shared Catarina Melo· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Albena T. Dinkova‐KostovaORCID

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2 papers

Recent·Most cited

The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2.

Jialin Feng, Mara Carreño, Hannah Jung, Sharadha Dayalan Naidu, Nicole M. Arroyo-Díaz, Abel Damien Ang, Bhargavi Kulkarni, Dorothy Kisielewski, Takafumi Suzuki, Masayuki P. Yamamoto, John D. Hayes, Tadashi Honda, Landon Shay Wilson, Beatriz León, Aimee L. Eggler, , Albena T. Dinkova‐Kostova

This study shows that kynurenine-CKA targets C151 in Keap1 to increase Nrf2 activity and anti-inflammatory effects in macrophages.

Redox Biology · Jan 6, 2026Peer-reviewedBiochemistry

Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy

Susana G. Martins, Vanessa Ribeiro, Catarina Melo, Cláudia Paulino-Cavaco, Dario Antonini, Sharadha Dayalan Naidu, Fernanda Murtinheira, Inês T.E. Fonseca, Bérénice Saget, Mafalda Pita, Diogo R. Fernandes, Pedro Gameiro dos Santos, Gabriela Rodrigues, Rita Zilhão, Federico Herrera, , Sólveig Þorsteinsdóttir

This study investigates the early molecular changes in LAMA2-CMD using a mouse model, identifying gene expression, cytoskeletal, and DNA repair defects at disease onset.

Life Science Alliance · Oct 8, 2024Peer-reviewedDevelopmental Biology