The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells
Guanyin Huang, Xiaolong Xu, Binyu Zhang, Mao Zhao, Yixin Cheng, Boxi Zhao, Shuqian Zheng, Xuefei Liu, Songyan Yu, Liuyang Wang, Jianyang Hu, Chunhao Long, Yu Zhang, Yuling Sheng, Siyuan Xia, , Xin Hong
This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.
bioRxiv · Aug 20, 2026 · PreprintCancer Biology