Author

Jianyang Hu

Guangzhou University of Chinese MedicineORCID 0000-0003-4911-6816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Binyu ZhangiD· 2 shared Guanyin Huang· 2 shared Hao YuiD· 2 shared Shuqian ZhengiD· 2 shared Xuefei LiuiD· 2 shared Boxi Zhao· 1 shared Chunhao Long· 1 shared Fan Yang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Binyu ZhangORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 20, 2026

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

Guanyin Huang, Xiaolong Xu, Binyu Zhang…·Xin Hong

This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.

DOI 10.64898/2026.08.19.745859

humanscRNA-seq

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Cancer BiologybioRxivPreprintMar 26, 2025

Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence

Jianyang Hu, Binyu Zhang, Junhao Chen…·Xin Hong

This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.

DOI 10.1101/2025.03.26.645381

humanproteomics

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