Hui Yang

This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.

The paper introduces an automated AI pipeline for correlating chemical and ultrastructural images to enable organelle-specific molecular imaging in cells and tissues.

This paper develops a near-infrared II calcium imaging technique using a bacterial protein to enable high-sensitivity, non-invasive deep-tissue calcium imaging in live mammals.

This paper develops two deaminase-free base editors, gTBE and gCBE, for direct T and C editing using engineered UNG variants, achieving high editing efficiencies in human cells.

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

This paper develops a long-deletion mouse model of Williams syndrome to study vascular and neural phenotypes, finding that Ncf1 modulates both cardiovascular and neuropsychological symptoms.

This paper engineers a TnpB-ωRNA system for efficient gene editing in mice, showing improved activity over Cas12f1 and successful disease prevention in a tyrosinaemia model.

This study uses interspecies blastocyst complementation to generate functional rat-derived forebrain tissues in mice, revealing developmental and xenogeneic barriers.

This study shows that Ptbp1 knockdown in mouse striatum using an AAV-based system does not induce astrocyte-to-neuron conversion, contrasting previous reports.

The paper develops an optimized AAV-based labeling system for Muller glia in mice, showing improved efficiency and specificity compared to existing methods.

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

The paper identifies two enhancers critical for TAAR gene expression in olfactory sensory neurons and shows they operate in cis to regulate gene choice.

The paper predicts meiosis-essential genes by analyzing dynamic proteomes from spermatogenesis-synchronized mice and validates four candidates using knockout models.

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.

This study shows doxorubicin enhances rAAV-mediated gene expression in the cortex of mice, cats, and monkeys, with effects observed across multiple serotypes and without significant cytotoxicity.

This study demonstrates the use of CasRx-mediated RNA knockdown to modulate metabolic genes in mouse liver, showing efficient and reversible reduction of PCSK9 and cholesterol levels.

The paper identifies base editor variants with reduced off-target effects on both DNA and RNA.

This study compares off-target single nucleotide variants (SNVs) from CRISPR-Cas9 and base editing (BE3) in mouse embryos using the GOTI method, finding BE3 causes significantly more SNVs.