Author

Guanyin Huang

Southern University of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Binyu ZhangiD· 2 shared Hao YuiD· 2 shared Jianyang HuiD· 2 shared Shuqian ZhengiD· 2 shared Xuefei LiuiD· 2 shared Boxi Zhao· 1 shared Chunhao Long· 1 shared Fan Yang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Binyu ZhangORCID

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2 papers

Recent·Most cited

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

Guanyin Huang, Xiaolong Xu, Binyu Zhang, Mao Zhao, Yixin Cheng, Boxi Zhao, Shuqian Zheng, Xuefei Liu, Songyan Yu, Liuyang Wang, Jianyang Hu, Chunhao Long, Yu Zhang, Yuling Sheng, Siyuan Xia, , Xin Hong

This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.

bioRxiv · Aug 20, 2026 · PreprintCancer Biology

Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence

Jianyang Hu, Binyu Zhang, Junhao Chen, Guanyin Huang, Hongchao Zhou, Fan Yang, Ke Liu, Shuqian Zheng, Xuefei Liu, Jia-Ling Liu, Hailiang Hu, Lvhua Wang, Jianglin Zhang, Lingyun Dai, Qingfeng Chen, , Xin Hong

This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.

bioRxiv · Mar 26, 2025 · PreprintCancer Biology