Author

Jian-Xiong Chen

University of Mississippi Medical Center

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Physiology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Dongzhi WangiD· 1 shared Heng ZengiD· 1 shared John S. ClemmeriD· 1 shared Lei Hou· 1 shared Lihong PaniD· 1 shared Umesh BhattaraiiD· 1 shared Xiaochen HeiD· 1 shared Yingjie CheniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperPhysiology

Dongzhi WangORCID

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1 paper

Recent·Most cited

IL27 exerts a powerful effect on systolic overload-induced cardiac inflammation, fibrosis, and heart failure development

Ziru Niu, Umesh Bhattarai, Dongzhi Wang, Xiaochen He, Lihong Pan, Heng Zeng, Jian-Xiong Chen, John S. Clemmer, Lei Hou, Yingjie Chen

This study shows IL-27 promotes cardiac inflammation, fibrosis, and heart failure in mice by modulating immune and non-immune cells, suggesting it as a therapeutic target.

Redox Biology · Oct 1, 2026Peer-reviewedPhysiology