Author

Ziru Niu

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Dongzhi WangiD· 2 shared Heng ZengiD· 2 shared John S. ClemmeriD· 2 shared Lihong PaniD· 2 shared Umesh BhattaraiiD· 2 shared Xiaochen HeiD· 2 shared Yingjie CheniD· 2 shared Hao WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersPhysiology

Dongzhi WangORCID

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2 papers

Recent·Most cited

IL27 exerts a powerful effect on systolic overload-induced cardiac inflammation, fibrosis, and heart failure development

Ziru Niu, Umesh Bhattarai, Dongzhi Wang, Xiaochen He, Lihong Pan, Heng Zeng, Jian-Xiong Chen, John S. Clemmer, Lei Hou, Yingjie Chen

This study shows IL-27 promotes cardiac inflammation, fibrosis, and heart failure in mice by modulating immune and non-immune cells, suggesting it as a therapeutic target.

Redox Biology · Oct 1, 2026Peer-reviewedPhysiology

Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

Umesh Bhattarai, Xiaochen He, Ziru Niu, Lihong Pan, Dongzhi Wang, Hao Wang, Heng Zeng, Jian‐Xiong Chen, Joshua S. Speed, John S. Clemmer, John Edward Hall, Yingjie Chen

This study shows that genetic inhibition of IL-12β reduces cardiac inflammation and heart failure in mice subjected to transverse aortic constriction.

bioRxiv · Sep 5, 2025 · PreprintPhysiology