Functional coupling of TRPM2 and NMDARs exacerbates excitotoxicity in ischemic brain injury
Pengyu Zong, Jianlin Feng, Zhichao Yue, Gongxiong Wu, Baonan Sun, Yanlin He, Barbara A. Miller, Albert S. Yu, Zhongping Su, Yasuo Mori, Jia Xie, Lixia Yue
The paper identifies a novel mechanism where TRPM2 interacts with NMDARs to enhance excitotoxicity in ischemic stroke and develops a peptide to block this interaction, offering a new therapeutic strategy.
bioRxiv · Jul 29, 2021 · PreprintNeuroscience