Author

Jia Xie

University of ConnecticutORCID 0009-0009-3565-1237Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jia Xie1 paper · Shanghai Jiao Tong University

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aks ChiangiD· 1 shared Albert S. YuiD· 1 shared Baonan SuniD· 1 shared Barbara A. MilleriD· 1 shared Gongxiong Wu· 1 shared Jianlin Feng· 1 shared Kam Pui Tam· 1 shared Lixia YueiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Aks ChiangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in post-transplant lymphoproliferative disorder

Kam Pui Tam, Jia Xie, Rex K.H. Au-Yeung, Aks Chiang

This paper shows that combining bortezomib and venetoclax kills PTLD cells by targeting EBV proteins LMP-1 and EBNA-3C through proteasome inhibition and Bcl-2 suppression.

bioRxiv · May 13, 2024 · PreprintMolecular Biology

Functional coupling of TRPM2 and NMDARs exacerbates excitotoxicity in ischemic brain injury

Pengyu Zong, Jianlin Feng, Zhichao Yue, Gongxiong Wu, Baonan Sun, Yanlin He, Barbara A. Miller, Albert S. Yu, Zhongping Su, Yasuo Mori, Jia Xie, Lixia Yue

The paper identifies a novel mechanism where TRPM2 interacts with NMDARs to enhance excitotoxicity in ischemic stroke and develops a peptide to block this interaction, offering a new therapeutic strategy.

bioRxiv · Jul 29, 2021 · PreprintNeuroscience