Jianqiang Zhang

Porcine epidemic diarrhea virus infection promotes Peyer's patch immune induction and epithelial defense via single-cell transcriptional reprogramming

This study uses scRNA-seq to analyze how PEDV infection alters transcriptional responses in intestinal epithelial and immune cells, identifying a conserved antiviral gene signature in enterocytes.

Evaluation of gaseous ozone technology for decontaminating porcine reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea virus (PEDV) from non-porous surface in truck cabins

This study evaluates gaseous ozone's effectiveness in decontaminating PRRSV and PEDV from truck cabin surfaces, finding inconsistent and limited viral titer reduction.

United States PRRSV 1-4-4 L1C.5 isolate demonstrates similar pathogenicity to a historic Chinese highly pathogenic PRRSV

This study compares the pathogenicity of PRRSV 1-4-4 L1C.5 to historical Chinese HP-PRRSV JXwn06 and US strain MN184 in weaned pigs, finding L1C.5 and JXwn06 cause more severe disease than MN184.

PRRSV-2 variant classification: a dynamic nomenclature for enhanced monitoring and surveillance

This paper introduces a dynamic classification system for PRRSV-2 genetic variants using clustering algorithms and demonstrates its effectiveness in tracking genetic diversity over time.

Phylogenetic-based methods for fine-scale classification of PRRSV-2 ORF5 sequences: a comparison of their robustness and reproducibility

This study compares phylogenetic-based methods for fine-scale classification of PRRSV-2 ORF5 sequences, identifying robust approaches that improve resolution over RFLP-typing.

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattle

The paper identifies a new genotype of HPAI H5N1 virus in dairy cattle, showing genetic changes but lacking key mutations for mammalian adaptation.

Rapid genotyping of porcine reproductive and respiratory syndrome virus (PRRSV) using MinION nanopore sequencing

This paper develops and optimizes MinION nanopore sequencing methods for rapid genotyping of PRRSV, achieving high sequence identity and coverage in clinical samples.

The United States Swine Pathogen Database: integrating veterinary diagnostic laboratory sequence data to monitor emerging pathogens of swine

The paper develops a centralized database for swine pathogen sequences to monitor emerging pathogens and support genomic surveillance.