Author

Tyron Chang

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dustin C. HancksiD· 3 shared Jessica AlvareziD· 2 shared Mahsa SorouriiD· 2 shared Alexandra BuckleyiD· 1 shared Andrew S. LemoffiD· 1 shared Bailey L. ArrudaiD· 1 shared Chelsea PinkhamiD· 1 shared Eraldo Lourenso ZanellaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

Dustin C. HancksORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial perturbation adapts the proteome from early to advanced immune responses

Jessica Alvarez, Sofia Rivera, Sarahbeth Roberts, Natalia E Herrera, Tyron Chang, Krishna Kanth Chitta, Jeon Lee, Andrew S. Lemoff, Dustin C. Hancks

The paper shows mitochondrial state influences protein-level immune responses, with OXPHOS supporting early immune proteins and mitochondrial perturbation favoring inflammatory mediators in mice.

bioRxiv · Sep 14, 2026 · PreprintImmunology

United States PRRSV 1-4-4 L1C.5 isolate demonstrates similar pathogenicity to a historic Chinese highly pathogenic PRRSV

Jayne E Wiarda, Bailey L. Arruda, Tavis K. Anderson, Sarah J. Anderson, Hanjun Kim, Tyron Chang, Lauren Tidgren Hanson, Eraldo Lourenso Zanella, Samantha J. Hau, Meghan Wymore Brand, Jianqiang Zhang, Alexandra Buckley

This study compares the pathogenicity of PRRSV 1-4-4 L1C.5 to historical Chinese HP-PRRSV JXwn06 and US strain MN184 in weaned pigs, finding L1C.5 and JXwn06 cause more severe disease than MN184.

Virology · Nov 26, 2025Peer-reviewedMicrobiology

Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-g induced IRF1

Tyron Chang, Jessica Alvarez, Sruthi Chappidi, Stacey L. Crockett, Mahsa Sorouri, Robert C. Orchard, Dustin C. Hancks

This study shows that glucose and galactose metabolism affects IRF1 stability, which in turn influences vaccinia virus replication outcomes.

PLoS Pathogens · Oct 30, 2024Peer-reviewedMicrobiology

MISTR: A conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict

Mahsa Sorouri, Tyron Chang, Palmy R. R. Jesudhasan, Chelsea Pinkham, Nels C. Elde, Dustin C. Hancks

The paper identifies a conserved mitochondrial stress response network (MISTR) by analyzing evolutionary conflict signatures across species, revealing its role in stress response and pathogen resistance.

PLoS Biology · Dec 28, 2020Peer-reviewedGenetics