hPSC-Derived Distal Lung Organoids Reveal Respiratory Airway Secretory Cells Acting as Immune Sentinels in Human Distal Airways
Jiaqi Sun, Shisheng Jiang, Hui Sun, Xiaoxiao Xie, Hao Meng, Dong Wang, Hongjie Yao, Jianwei Dai, Hui Zheng, Wei‐jie Guan, Jincun Zhao, Wei Kevin Zhang, Tao Xu, Huisheng Liu
This study uses hPSC-derived distal lung organoids to identify RAS cells as immune sentinels in human distal airways, revealing their roles in viral, bacterial responses, and COPD.
bioRxiv · Mar 24, 2025 · PreprintCell Biology