FMR1 reduction alters cellular and circuit properties in human cortex
Aditi Singh, Saman Abbaspoor, Leeyup Chung, Maxwell J. Heinrich, Scellig S. D. Stone, Hart G.W. Lidov, Beatriz Maio, Phuoc Tien Tran, Jaeyoung Yoon, Jiawen Teng, Catalina Martínez, Elijah Hammarlund, Xiguang Xu, Alexander Rotenberg, Jeffrey P. Gavornik, , Emily K. Osterweil
This study reduces FMR1 expression in human cortical slices to model Fragile X syndrome, revealing cell type-specific transcriptomic and electrophysiological changes not observed in mouse models.
bioRxiv · Mar 12, 2026 · PreprintNeuroscience