Maxwell J. Heinrich

This study reduces FMR1 expression in human cortical slices to model Fragile X syndrome, revealing cell type-specific transcriptomic and electrophysiological changes not observed in mouse models.

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

The paper identifies a shared electrophysiological biomarker of Fragile X Syndrome in human and mouse models, showing slowed alpha oscillations linked to FMRP loss in excitatory neurons.