Investigation of Regulation and Binding Patterns of the Human Cathelicidin Peptide LL-37 in Complexation with Nucleic Acids, and its Impact on Neutrophil Extracellular Traps
Claudia Zielke, Behzad Rad, Josefine Eilsø Nielsen, Jiaxin Li, Sopida Pimcharoen, Manasi Sawant, Jennifer S Lin, Hawa Racine Thiam, Annelise E. Barron
This study investigates how LL-37 binds to nucleic acids, forming complexes that affect DNA structure and NET clearance, with implications for immune regulation and disease.
bioRxiv · Feb 11, 2026 · PreprintBiophysics