Manasi Sawant

Benchmarking three simple DNA staining-based image metrics for live-cell tracking of chromatin organization

The paper benchmarks three live-cell image metrics for quantifying chromatin organization changes, showing they correlate with chromatin accessibility and track chromatin dynamics in different biological processes.

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression

The paper investigates how chromatin organization affects cell mechanics during NETosis, finding that chromatin decompaction increases plasma membrane tension and cell volume independently of gene expression.

Investigation of Regulation and Binding Patterns of the Human Cathelicidin Peptide LL-37 in Complexation with Nucleic Acids, and its Impact on Neutrophil Extracellular Traps

This study investigates how LL-37 binds to nucleic acids, forming complexes that affect DNA structure and NET clearance, with implications for immune regulation and disease.

Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex

The paper identifies autoantibody hotspots on the XIST RNP complex in female-biased autoimmune diseases and links them to clinical outcomes.