Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages
Ruixue Ma, Li Gong, Chao Dong, Teruo Utsumi, Jiewen Qi, Zhen W. Zhuang, Xuchen Zhang, Yilin Yang, Matthew J. McConnell, Hui‐Chun Huang, Yasuko Iwakiri
This study shows that increased VCAM-1 in hepatic artery endothelial cells and portal fibroblasts recruits Spp1+ macrophages, driving fibrosis in portal hypertension.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedPathology